Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewaterArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha variant analyzed application applied assays can be used collected Community coronavirus coronavirus disease COVID-19 delta variant demonstrated detect eight epidemiologically FIVE Health High-throughput qPCR highlighting increase Japan L452R labor-intensive likelihood Mie N501Y nine nucleotide nucleotide substitution pathogenic virus pathogenic viruses Pathogenic viruses, SARS-CoV-2 Patient PCR positive prevalent qPCR quantitative PCR quarantine reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant separated Surveillance target tested time-consuming Treatment virus viruses Volume wastewater Wastewater. Yokkaichi [DOI] 10.1016/j.scitotenv.2022.158659 PMC 바로가기
SARS-CoV-2 shedding dynamics and transmission in immunosuppressed patients면역 억제 환자의 SARS-CoV-2 발산 역학 및 전파Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjust analysed anatomic site characterized collected conducted coronavirus Diagnosis Diversity dominant E484K first positive fitness genetic change Genome genomic Host hosts household transmission Immunosuppressed immunosuppressed patient immunosuppressed patients in urine in vivo Infection Interaction knowledge long-term viral shedding mother mutate Mutation mutation dynamics N501Y occurred P681R Patient replicate residue residues SARS-CoV-2 SARS-CoV-2 evolution selective Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Spike protein spread to Substitution temporal dynamics Transmission two patients Urine variant variant of concern variants variants of concern virus whole genome Whole genome sequencing whole genome sequencing. whole-genome sequencing [DOI] 10.1080/21505594.2022.2101198 PMC 바로가기 [Article Type] Article
Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assaysArticle Published on 2022-12-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Accuracy acute respiratory syndrome approach B.1.1.7 B.1.526 clinical setting Concordance coronavirus coronavirus disease 19 Coronavirus disease 19 (COVID-19) E484K evaluated genotyping mutations N501Y nasopharyngeal Negative predictive value New York City nonsynonymous patient population polymorphism positive positive sample predicted ranged Rapid Real-time reverse-transcription PCR residual RT-qPCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant sensitivity Sequencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly lower single nucleotide specificity Spike protein submitted subset TaqMan TaqMan assay Thermofisher variant variants variants of concern. were used WGS whole genome [DOI] 10.1016/j.diagmicrobio.2022.115789 PMC 바로가기
Pathogen-host adhesion between SARS-CoV-2 spike proteins from different variants and human ACE2 studied at single-molecule and single-cell levelsArticle Published on 2022-12-012022-11-16 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2-RBD acute respiratory syndrome addition adhere binding complex coronavirus Delta delta variant destabilized effective force spectroscopy highest host cell human ACE2 human Angiotensin-converting enzyme immunization Infection inhibit Interaction investigated molecular dynamics molecular mechanism monoclonal antibody Mutation mutations N501Y Neutralizing neutralizing antibody omicron pathogen-host adhesion. Probability produced RBD Receptor binding domain S477N SARS-CoV-2 SARS-CoV-2 spike protein single-cell single-cell level Spike protein tested the spike protein variant variants virus wild type [DOI] 10.1080/22221751.2022.2128887 PMC 바로가기
Wastewater surveillance allows early detection of SARS-CoV-2 omicron in North Rhine-Westphalia, GermanyArticle Published on 2022-11-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach close monitoring collected COVID-19 COVID-19 surveillance demonstrated detection Detection workflow dominant variant Epidemiology evaluate fraction Germany identify Initially K417N Laboratory Local MONITOR mutant Mutation N501Y NGS North omicron Omicron, B.1.1.529 PCR primer public health purified Regulation required resulting RT-qPCR SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 monitoring SARS-CoV-2 RNA SARS-CoV-2 variant Sequencing state subsequent Support Surveillance Treatment variant variant of concern was performed wastewater Wastewater-based epidemiology (WBE). [DOI] 10.1016/j.scitotenv.2022.157375 PMC 바로가기
The effect of mutations on binding interactions between the SARS-CoV-2 receptor binding domain and neutralizing antibodies B38 and CB6Article Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] antibodies antibody Antibody escape mutation binding binding interaction claimed COVID-19 human population IMPROVE molecular Mutation mutations N501Y Neutralizing antibodies neutralizing antibody pathogen Potential treatment predicted previous study Receptor binding domain responsible resulting S-RBD SARS-CoV-2 severity of COVID-19 the SARS-CoV-2 therapeutic [DOI] 10.1038/s41598-022-23482-5 PMC 바로가기
SARS-CoV-2 quasi-species analysis from patients with persistent nasopharyngeal sheddingArticle Published on 2022-11-042022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Analysis asked both groups clade Consequences Control COVID 19 deviation Evolution of SARS-CoV-2 genomic greater Human immune system immune evasion increase Infectious virus Interaction intra-individual investigated Mutation N501Y nasopharyngeal no significant difference P681H pandemic Patient patients performed persistence Prevent question RNA virus SARS-CoV-2 Sequencing Standard survival the SARS-CoV-2 therapeutic two group Variability variants viral propagation viral variant [DOI] 10.1038/s41598-022-22060-z PMC 바로가기
Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variantArticle Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Angiotensin-converting enzyme coronavirus COVID-19 domain Effect ENhance human ACE2 human Angiotensin-converting enzyme humans infect investigated mouse angiotensin-converting enzyme 2 Mutation Mutational hotspots N501Y Omicron variant question raised RBD receptor Receptor-binding domain (RBD). SARS-CoV-2 Spread the RBD viral adaptation X-ray X-ray crystallography [DOI] 10.1073/pnas.2206509119 PMC 바로가기
In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 bindingSARS-CoV-2 스파이크 단백질 N501Y 및 N501T 돌연변이가 인간 ACE2 결합에 미치는 영향에 대한 실리코 분석Article Published on 2022-11-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed anti-SARS-CoV-2 antibodies Anti-viral drugs antisense attachment binding binding energy binding free energy classic Dynamics Effect Effect of mutations on binding energy effective free energy hACE2 hACE2 receptor hACE2-SARS-CoV-2 spike protein binding. handling highlight Host human ACE2 maintain molecular molecular dynamics molecular dynamics simulations Mutation N501Y N501Y and N501T mutations nine outcome predicted Protein binding raised Replication SARS CoV SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 spike protein Spike protein survival Transmissibility treatment strategy Vaccines virus [DOI] 10.1016/j.jmgm.2022.108260 PMC 바로가기 [Article Type] Article
Omicron (B.1.1.529) – A new heavily mutated variant: Mapped location and probable properties of its mutations with an emphasis on S-glycoproteinArticle Published on 2022-10-312022-11-16 Journal: International journal of biological macromolecules [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 receptor addition Analysis analyzed antibodies antibody Antibody binding B.1.1.529 bioinformatics characterized contribute country D614G eight human ACE2 receptor information investigated K417N mapped molecular mutated Mutation mutations N501Y NAb nAb escape. omicron outcome performed Quotient RBD RBD mutation recorded Region reported Research S477N SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC Seven spike spike mutation Spread statistical the binding affinity the RBD the SARS-CoV-2 variant while ΔΔG [DOI] 10.1016/j.ijbiomac.2022.07.254 PMC 바로가기